According to the Food Drug Administration, in 2021, the number of drug interaction patients is increasing in Pakistan, which is a burning issue among the medicinal health problem. The common mob must understand the drug interaction effects and how they would be controlled with the help of food supplements.
Otherwise, drug interaction not only affects the patient’s present condition but paralyzed and creates more severe health problems for them, and at last, the patient has been died due to such types of dangerous condition. Such circumstances burden families, caregivers, health departments, health professionals, and practitioners. This article brings a unique solution for the affected drug interaction patients with the persistent use of food supplements.
A different solution has been prescribed for controlling the drug interaction by using food supplements for the patient. Food supplements might lower the side effects of the drug interaction and enhance the benefits of a drug for current disease patients. Some drug interactions might be harmful to health. Whenever the patient took a prescription or over-the-counter medication, the label was checked, and learned about possible drug interactions. To avoid potentially dangerous pharmaceutical interactions and side effects, we need to know a little knowledge and common sense about food and drug interaction.
Food-drug interactions may significantly impact certain medicines’ therapeutic (healing of disease) efficacy with a restricted therapeutic (treatment) range. It is also possible that food-drug interactions alter the therapeutic effectiveness of medication by altering its pharmacokinetic processes, including the drug’s absorption and distribution, as well as its metabolism and excretion.
Observing the effects of highly active antiretroviral therapy (HAART) drugs and nutrition on therapy results is crucial because they interact in various ways. Such as, pharmacokinetic factors, including maximum plasma concentration (Cmax), the area under the curve (AUC), time to maximum concentration (Tmax), and terminal half-life (t1/2), are all affected by food intake in the treatment. In a similar vein, the World Health Organization published in 2021, that food supplement considerations are necessary to control the high effect of drug interaction. Because pharmacokinetic modifications in HAART became a clinical problem due to their concurrent administration with food or nutritional supplements, it is vital to assess HAART’s therapeutic effectiveness in patients living.
Researchers performed a systematic review to understand better the pharmacokinetic effects of the interaction between HAART and supplements such as meals, nutritional supplements, and minerals. The time to attain maximum concentration (tmax) of HAART includes abacavir, amprenavir, darunavir, emtricitabine, lamivudine, zidovudine, ritonavir, and tenofovir alafenamide were substantially enhanced when food drug food-drug interaction was used.
In conclusion, the maximum plasma concentration (Cmax) of HAART-like darunavir rose in starving situations, which was unaffected under the curve and the terminal half-life of the drug interaction patients. In response, the clinical trials of HAART and specific food supplement interactions are required to assess the pharmacokinetic features. One of the most effective suggestions for patients is to be educated about the side effects of drug interactions and to take food supplements before using the medicine.